I put on glider gap seals and now 250 hours later, most are still in place. My approach: sanded the area where the adhesive hits the paint with 1500 sand paper after having wiped with acetone, heat gun to drive out residual acetone that may have remained, putting down masking tape to prevent sanding out of bounds, and then after applying tapes, repeated passes pushing down hard with my thumbs - time and pressure being assumed necessary to make the adhesive flow into the tiny scratches. Not perfect, but seems to last better than experience of others.
As for their effect, I assume small potatoes, but it all adds up.
Fred