I'm aware of two non-incidents of canopy open in-flight in a Lancair 320. First was an unintentional takeoff with canopy unlatched. When I noticed it shortly after becoming airborne, I continued the takeoff, entered closed traffic, landed, latched the canopy and took off again. No big deal (except my checklist following failure). The second non-incident was a physical failure of my latch system while airborne. I landed and fixed it.

There were absolutely no problems flying with the canopy open about two inches. None whatsoever!